
Southwest Chicken Casserole is a hearty, flavor-packed dish that brings together tender chicken, black beans, corn, and rice, all baked in a zesty, creamy sauce. It’s seasoned with southwest spices like cumin, chili powder, and paprika, then topped with melty cheese for the ultimate comfort food experience. This casserole is warm, cheesy, and filled with bold flavors, perfect for satisfying your Tex-Mex cravings.
I first made Southwest Chicken Casserole when I needed a one-dish dinner that was both easy to make and bursting with flavor, and it didn’t disappoint! The combination of creamy sauce, tender chicken, and cheesy goodness is incredibly comforting. What I love most about this recipe is how customizable it is—you can add jalapeños for extra heat, swap the rice for quinoa, or top it with fresh cilantro, avocado, or a dollop of sour cream for added freshness. Whether for a weeknight dinner or meal prep, this casserole is a guaranteed hit!
Perfect for:
- Weeknight dinners
- Family gatherings
- Potlucks
- Comfort food lovers
- Meal prep
Why You’ll Love This Recipe
Here are 10 reasons why this Southwest Chicken Casserole will quickly become your go-to dish:
- Bold Flavor: A blend of southwestern spices adds a kick to the tender chicken and vegetables.
- Cheesy Goodness: The melted cheese topping is irresistible and ties all the flavors together.
- One-Pan Meal: This casserole is easy to prepare, with minimal cleanup required.
- Customizable: Adjust the heat level by varying the amount of chili powder or adding jalapeños.
- Healthy and Hearty: Packed with protein and vegetables, it’s a filling meal that satisfies.
- Comfort Food at Its Best: With its warm, creamy texture, this casserole is perfect for cozy nights.
- Perfect for Leftovers: This casserole stores well and makes for great leftovers.
- Easy to Make Ahead: Prepare it in advance and pop it in the oven when ready to serve.
- Kid-Friendly: The cheesy, savory flavors appeal to kids and adults alike.
- Great for Meal Prep: Prepare a large batch and portion it out for lunches or dinners throughout the week.
Preparation and Cooking Time
- Total Time: 1 hour
- Preparation Time: 15 minutes
- Cooking Time: 45 minutes
- Servings: 6 servings
- Calories per serving: Approximately 400-450 calories
- Key Nutrients: Protein: 35g, Carbs: 35g, Fat: 20g
Ingredients
For the Chicken and Vegetables:
- 2 cups cooked, shredded chicken
- 1 cup bell peppers, chopped
- 1 cup onions, chopped
- 1 cup corn kernels (frozen or fresh)
- 1 cup black beans, drained and rinsed
- 1 cup diced tomatoes, drained
The Sauce:
- 1 cup sour cream
- ½ cup mayonnaise
- 1 packet taco seasoning
- ½ teaspoon garlic powder
- ½ teaspoon onion powder
- 1 teaspoon chili powder
- 1 teaspoon cumin
- Salt and pepper to taste
For Topping:
- 1 ½ cups shredded cheddar cheese
- 1 cup tortilla chips, crushed
Ingredient Highlights
- Shredded Chicken: Provides lean protein and a hearty texture to the casserole.
- Taco Seasoning: Adds a delicious blend of spices that gives the dish its southwest flavor.
- Sour Cream and Mayonnaise: Create a creamy base that perfectly complements the spiced chicken and vegetables.
- Cheddar Cheese: Melts beautifully over the casserole, giving it a golden, cheesy crust.
Step-by-Step Instructions
Prepare the Chicken and Vegetables:
- Preheat Oven: Preheat your oven to 375°F (190°C). Grease a 9×13-inch baking dish.
- Cook Chicken: If not already cooked, sauté the chicken in a pan until fully cooked, then shred it.
- Cook Vegetables: In a large skillet, sauté the bell peppers and onions until soft. Add the corn, black beans, and diced tomatoes, and cook for another 5 minutes.
Make the Sauce:
- Mix Sauce Ingredients: In a bowl, combine sour cream, mayonnaise, taco seasoning, garlic powder, onion powder, chili powder, cumin, salt, and pepper. Stir until smooth.
Assemble the Casserole:
- Combine Chicken and Veggies with Sauce: In a large bowl, combine the shredded chicken, sautéed vegetables, and sauce. Mix well.
- Transfer to Baking Dish: Pour the mixture into the prepared baking dish, spreading it evenly.
Add Toppings:
- Top with Cheese: Sprinkle shredded cheddar cheese over the top of the casserole.
- Add Crushed Tortilla Chips: Sprinkle crushed tortilla chips on top of the cheese for an extra crunchy finish.
Bake the Casserole:
- Bake: Place the casserole in the preheated oven and bake for 30-35 minutes, or until the cheese is melted and bubbly.
- Cool Slightly: Let the casserole cool for a few minutes before serving.
Serve:
- Garnish and Serve: Optionally, garnish with chopped cilantro or a dollop of sour cream. Serve hot and enjoy!

How to Serve
Here are 10 serving suggestions for Southwest Chicken Casserole:
- With a Side Salad: Pair with a fresh green salad for a balanced meal.
- With Guacamole: Serve with a side of homemade guacamole for extra creaminess.
- With Salsa: Add a spoonful of your favorite salsa for a tangy kick.
- As a Wrap: Serve in a tortilla wrap for a quick, handheld meal.
- With Rice or Quinoa: Serve over a bed of rice or quinoa for added fiber and bulk.
- With a Dollop of Sour Cream: Add a dollop of sour cream on top for extra creaminess.
- For Taco Night: Serve as a casserole alternative to traditional tacos.
- For a Picnic: Portion into individual servings and take to a picnic.
- With Jalapeños: Add sliced jalapeños on top for a spicy twist.
- For Leftovers: Enjoy it the next day as a quick, reheated meal.
Additional Tips
- Customize the Heat: Adjust the spice level by adding more chili powder or diced jalapeños.
- Make It Lighter: Use Greek yogurt instead of sour cream for a lighter version of the sauce.
- Keep It Crispy: Add the tortilla chips toward the end of the baking time to keep them crispy.
- Use Rotisserie Chicken: For a quicker meal, use pre-cooked rotisserie chicken.
- Make It Vegetarian: Skip the chicken and add extra beans or vegetables for a vegetarian version.
Recipe Variations
- Buffalo Chicken Casserole: Swap taco seasoning for buffalo sauce and add blue cheese for a tangy twist.
- Gluten-Free Version: Use gluten-free tortilla chips and ensure all other ingredients are gluten-free.
- Vegan Southwest Casserole: Use plant-based cheese and vegan mayo or sour cream for a vegan-friendly option.
- Spicy Southwest Chicken Casserole: Add more chili powder or jalapeños for an extra fiery kick.
- Chicken and Spinach Casserole: Add fresh spinach to the mix for added greens.
- Cheesy Enchilada Casserole: Layer the casserole with enchilada sauce for a more intense flavor.
Special Equipment
- Large Skillet: For sautéing the vegetables and cooking the chicken.
- 9×13-inch Baking Dish: Ideal for baking the casserole.
- Mixing Bowls: For combining the sauce and chicken mixture.
- Measuring Spoons and Cups: To ensure accurate measurement of spices and ingredients.
- Wooden Spoon: For stirring the ingredients together.
FAQ Section
- Can I use frozen chicken?
Yes, you can use frozen chicken, but make sure to thaw it fully before cooking. - Can I freeze this casserole?
Yes, it freezes well. Assemble the casserole and freeze before baking. When ready to serve, bake from frozen, adding extra time as needed. - How long does this casserole last in the fridge?
The casserole can be stored in the fridge for up to 3 days in an airtight container. - Can I add more vegetables?
Absolutely! Feel free to add vegetables like zucchini, mushrooms, or tomatoes for extra flavor and nutrition. - Can I use Greek yogurt instead of sour cream?
Yes, Greek yogurt is a great substitute for sour cream in this recipe. - How do I keep the tortilla chips crispy?
Add the tortilla chips in the last 5-10 minutes of baking to keep them from becoming soggy. - Can I double the recipe?
Yes, simply double the ingredients and use a larger baking dish. - Can I use a different cheese?
You can use any cheese you prefer, such as Monterey Jack or a Mexican blend. - Can I make this casserole ahead of time?
Yes, assemble the casserole and refrigerate it for up to 24 hours before baking. - What can I use instead of black beans?
You can substitute black beans with pinto beans, kidney beans, or chickpeas.
Conclusion
Southwest Chicken Casserole is a flavorful and hearty dish that combines tender chicken with a blend of zesty southwestern spices, creamy cheese, and delicious vegetables. It’s the perfect comfort food for a family dinner or potluck. The base of the casserole typically includes shredded chicken, black beans, corn, bell peppers, and a combination of seasonings like cumin, chili powder, and garlic powder. The ingredients are then baked with a generous layer of cheese on top, creating a melty, golden crust.
To make it even more flavorful, you can use ingredients like salsa, sour cream, or a drizzle of ranch dressing. For extra crunch, you can add tortilla chips on top, giving the casserole a satisfying texture contrast. It’s a versatile recipe that you can customize with your favorite ingredients—such as adding diced tomatoes, jalapeños for extra heat, or even a bit of lime juice to brighten the flavors. Southwest Chicken Casserole is perfect for meal prepping, and the leftovers taste even better the next day. It’s an easy-to-make, crowd-pleasing dish that’s full of bold flavors and comforting textures.
I can’t wait to see how your Southwest Chicken Casserole turns out! Be sure to share your photos on Instagram and tag me—I’d love to see your flavorful creations. Don’t forget to leave a comment and let me know how you made this casserole your own!